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comC [2019-08-08 10:13:15]
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comC [2019-08-08 10:13:15]

late competence gene required for processing and translocation of ComGC, ComGD, ComGE and ComGG
locus
BSU_28070
pI
9.84
mw
26.37 kDa
protein length
248 aa Sequence Blast
gene length
747 bp Sequence Blast
function
genetic competence
product
processing protease
essential
no
synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.7|Genetic competence]
  • [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.5|Protein secretion]
  • [category|SW 4|Lifestyles] → [category|SW 4.1|Exponential and early post-exponential lifestyles] → [category|SW 4.1.3|Genetic competence]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

    • Gene

    Coordinates
    2,864,426 2,865,172

    The protein

    Catalyzed reaction/ biological activity

  • processing and translocation of [protein|19D76B80386F825109C5FB4A34881D5D20F366DB|ComGC], [protein|D323AEF5AFB4FD2A074ABAB76A39BE26A4C6436F|ComGD], [protein|FF4DB7FDCEB440064E11E65CB0DBFB93FC785CF0|ComGE] and [protein|89442BFDFBFF264D0C7F12DEA6F8130C55D1F3F8|ComGG] [Pubmed|9723928]
  • Typically cleaves a -Gly-|-Phe- bond to release an N-terminal, basic peptide of 5-8 residues from type IV prepilin, and then N-methylates the new N-terminal amino group, the methyl donor being S-adenosyl-L-methionine (according to Swiss-Prot)

    • Protein family

  • peptidase A24 family (single member, according to UniProt)

    • [SW|Localization]

  • integral membrane protein [Pubmed|24164455]

    • Expression and Regulation

    Operons

    genes
    [gene|57FDE2ABB5E9773717C23D727FD6CDA5D8CC3E36|comC]
    description
    [Pubmed|1694528]

    sigma factors

  • [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|1694528], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]

    • regulatory mechanism

  • [protein|08CFA2C72931A75532D4289BC1D18A826DE9F9CA|ComK]: activation, [Pubmed|8196543], in [regulon|08CFA2C72931A75532D4289BC1D18A826DE9F9CA|ComK regulon]
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    Biological materials

    Mutant

  • BKE28070 ([gene|57FDE2ABB5E9773717C23D727FD6CDA5D8CC3E36|comC]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE28070 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATAGACAACACACCTTTAC, downstream forward: _UP4_TGACTGCTGAAAAATTTGAC
  • BKK28070 ([gene|57FDE2ABB5E9773717C23D727FD6CDA5D8CC3E36|comC]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK28070 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATAGACAACACACCTTTAC, downstream forward: _UP4_TGACTGCTGAAAAATTTGAC

    • References

    Reviews

  • 15083159

    • Original publications

  • 9723928,16751195,7783624,2553669,1694528,8196543,24164455